Immune profiling after allogeneic hematopoietic cell transplantation in pediatric acute myeloid leukemia

Authors

Shahid, Sanam

Ceglia, Nicholas

Le Luduec, Jean-Benoît

McPherson, Andrew

8 more author(s)...

Description

Summary from GEO: "Although allogeneic hematopoietic cell transplantation (allo-HCT) is curative for high-risk pediatric acute myeloid leukemia (AML), disease relapse remains the primary cause of post-transplant mortality. To identify pressures imposed by allo-HCT on AML cells that escape the graft-versus-leukemia effect, we evaluated immune signatures in bone marrow samples from four pediatric patients...

Subject

Graft vs Leukemia Effect

Hematopoietic Stem Cell Transplantation

Leukemia, Myeloid, Acute

Single-Cell Gene Expression Analysis

T-Lymphocytes, Regulatory

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