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KMT2D suppresses Sonic Hedgehog-driven medulloblastoma progression and metastasis [ATAC-seq]
- Authors
- Sanghrajka, Reeti MayurKoche, Richard PatrickJoyner, Alexandra L.
- Description
Summary from GEO: "The major cause for treatment failure, morbidity and mortality amongst medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in SHH-driven medulloblastoma (SHH-MB) patients remain largely unknown. In this study we used mouse models of SHH-MB to define a tumor suppressive role of KMT2D (MLL4), a gene frequently...
- Subject
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Chromatin Immunoprecipitation SequencingHedgehog ProteinsHistone-Lysine N-MethyltransferaseMedulloblastomaNeoplasm Metastasis
- Access Rights
- Free to All
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KMT2D suppresses Sonic Hedgehog-driven medulloblastoma progression and metastasis [RNA-seq]
- Authors
- Sanghrajka, Reeti MayurKoche, Richard PatrickJoyner, Alexandra L.
- Description
Summary from GEO: "The major cause for treatment failure, morbidity and mortality amongst medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in SHH-driven medulloblastoma (SHH-MB) patients remain largely unknown. In this study we used mouse models of SHH-MB to define a tumor suppressive role of KMT2D (MLL4), a gene frequently...
- Subject
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Hedgehog ProteinsHistone-Lysine N-MethyltransferaseMedulloblastomaNeoplasm MetastasisRNA-Seq
- Access Rights
- Free to All
