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  • hPSC-derived Sacral Neural Crest Enables Rescue in a Severe Model of Hirschsprung’s Disease [ATAC-seq]

    Authors
    Fan, Yujie
    Description

    Summary from GEO: "The enteric nervous system (ENS) is derived from both the vagal and sacral component of the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human PSCs via timed exposure to FGF, WNT and to GDF11 to enable posterior patterning and transition from posterior trunk to sacral NC identity respectively. Using a SOX2::H2B-tdTomato/ T::H2B-GFP dual reporter...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Enteric Nervous System
    Heterografts
    Hirschsprung Disease
    Neural Crest
    Access Rights
    Free to All

  • hPSC-derived Sacral Neural Crest Enables Rescue in a Severe Model of Hirschsprung’s Disease [RNA-seq]

    Authors
    Fan, Yujie
    Description

    Summary from GEO: "The enteric nervous system (ENS) is derived from both the vagal and sacral component of the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human PSCs via timed exposure to FGF, WNT and to GDF11 to enable posterior patterning and transition from posterior trunk to sacral NC identity respectively. Using a SOX2::H2B-tdTomato/ T::H2B-GFP dual reporter...

    Subject
    Enteric Nervous System
    Heterografts
    Hirschsprung Disease
    Neural Crest
    RNA-Seq
    Access Rights
    Free to All