Calibrated CAR activation potential directs alternative T cell fates and therapeutic potency

Authors

Feucht, Judith Carolin

Sun, Jie

Eyquem, Justin Gabriel Andre Francois

Ho, Yu-jui

1 more author(s)...

Description

Summary from the GEO: "CD19-specific CARs that comprise CD28 and CD3z signaling domains program highly performing effector functions that mediate potent tumor elimination, but they impart a relatively limited T cell lifespan. Increasing functional T cell persistence without reducing effector potency is therefore likely to further enhance the therapeutic success of 1928z CAR T cells. We demonstrate...

Subject

Immunotherapy, Adoptive

Receptors, Antigen, T-Cell

T-Lymphocytes

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