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  • Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection

    Authors
    Randolph, Haley E.
    Fiege, Jessica K.
    Thielen, Beth K.
    Cobb, M.S.
    3 more author(s)...
    Description

    Description from GEO: "Humans show remarkable variation in susceptibility to infectious diseases as well as chronic inflammatory and autoimmune disorders. This heterogeneity arises partially from variation in the immune response, which is responsible for preventing and controlling infection. To better understand the major factors driving antiviral immune response differences, we used single-cell...

    Subject
    Autoimmune Diseases
    Inflammation
    Influenza A virus
    Influenza, Human
    Leukocytes, Mononuclear
    Single-Cell Gene Expression Analysis
    Access Rights
    Free to All
  • Influenza A response variation scripts

    Authors
    Randolph, Haley E.
    Description

    Description from Zenodo: "Input files and scripts to run the main analyses for influenza A virus (IAV) response variation project. The pipeline is published on GitHub as "IAV_population-variation" (https://github.com/herandolph/IAV_population-variation). " Description from GitHub: "code necessary to reproduce the main analyses published in: Genetic ancestry effects on the response to viral infection...

    Subject
    Immunity, Active
    Influenza A virus
    Viral Infections
    Access Rights
    Free to All