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  • IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice I

    Authors
    Song, Qingxiao
    Zeng, Defu
    Description

    Summary from the GEO: "CD4+ and CD8+ T cells can reciprocally differentiate into Th/Tc1, Th/Tc17 and Th/Tc22. Although alloreactive Th/Tc1 cells play a critical role in initiating pathogenesis of gut acute graft-versus-host disease (Gut-aGVHD), the pathogenic T cells in steroid-resistant Gut-aGVHD (SR-Gut-aGVHD) remains unclear. Here, we show that in murine models of SR-Gut-aGVHD, the pathogenesis...

    Subject
    Bacterial Translocation
    CD8-Positive T-Lymphocytes
    Chemokines, CX3C
    Dysbiosis
    Graft vs Host Disease
    Interleukin-17
    Interleukins
    Phagocytes
    Programmed Cell Death 1 Receptor
    T-Lymphocytes, Cytotoxic
    Access Rights
    Free to All

  • IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice II

    Authors
    Song, Qingxiao
    Zeng, Defu
    Description

    Summary from the GEO: "CD4+ and CD8+ T cells can reciprocally differentiate into Th/Tc1, Th/Tc17 and Th/Tc22. Although alloreactive Th/Tc1 cells play a critical role in initiating pathogenesis of gut acute graft-versus-host disease (Gut-aGVHD), the pathogenic T cells in steroid-resistant Gut-aGVHD (SR-Gut-aGVHD) remains unclear. Here, we show that in murine models of SR-Gut-aGVHD, the pathogenesis...

    Subject
    CD8-Positive T-Lymphocytes
    Dysbiosis
    Graft vs Host Disease
    Interleukin-17
    Interleukins
    T-Lymphocytes, Cytotoxic
    Access Rights
    Free to All