Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

Authors

Sawyers, Charles L.

Pe'er, Dana

Chan, Joseph

Karthaus, Wouter Richard

Description

Summary from GEO: "The inherent plasticity of tumor cells provides a mechanism of resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause of this lineage plasticity in a primary murine prostate organoid model that mirrors the lineage transition seen in patients. These cells lose...

Subject

Cell Lineage

Gene Deletion

Genes, Tumor Suppressor

Janus Kinases

Prostatic Neoplasms

Protein-Tyrosine Kinases

Single-Cell Analysis

Access Rights

Free to All