Alpha-ketoglutarate links p53 to cell fate during tumor suppression

Authors

Morris IV, John P.

Koche, Richard Patrick

Finley, Lydia Whitney Stillman

Lowe, Scott W.

Description

Summary from GEO: "The tumor suppressor p53 is mutated in the majority of human cancers, including pancreatic ductal adenocarcinoma (PDAC)1,2. Wild-type p53 accumulates in response to cellular stress and acts to regulate the expression of genes that influence cell fate and constrain tumorigenesis2. p53 also can modulate cellular metabolism3, though it remains unclear how the metabolic effects of...

Subject

Carcinogenesis

Carcinoma, Pancreatic Ductal

Chromatin Immunoprecipitation Sequencing

Ketoglutaric Acids

Tumor Suppressor Protein p53

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