MAP Kinase-Mutant Hematologic Malignancies and Their Therapeutic Resistance

Authors

Abdel-Wahab, Omar Ibrahim

Description

Description from dbGaP: "The Mitogen-Activated Protein Kinase (MAPK) signaling pathway has been critically important in understanding pathology and developing targeted therapy for many cancers, but high frequency mutations in this pathway in hematopoietic malignancies were unknown until a series of sequencing studies from our group and others revealed a high frequency of activating mutations in BRAF...

Subject

Hematologic Neoplasms

Leukemia, Hairy Cell

Mitogen-Activated Protein Kinases

Mutation

Receptor Protein-Tyrosine Kinases

Access Rights

Application Required