KDM6A(UTX) is an epigenetic gatekeeper of mTORC1 signalling in cancer

Authors

Revia, Steffie

Tschaharganeh, Darjus F.

Description

Summary from GEO: "Large-scale genome sequencing efforts of human tumors identified epigenetic modifiers as one of the most frequently mutated gene class in human cancer. However, how these mutations drive tumor development and progression is largely unknown. Here, we identify the histone demethylase KDM6A as an important tumor suppressor in solid cancers, such as liver cancer and pancreatic cancer....

Subject

Histone Demethylases

Liver Neoplasms

Mechanistic Target of Rapamycin Complex 1

Pancreatic Neoplasms

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