Single cell characterization of the immune microenvironment of melanoma brain and leptomeningeal metastases

Authors

Smalley, Inna

Chen, Zhihua

Smalley, Kieran S. M.

Chen, Y. Ann

Description

Summary from GEO: "Melanoma brain metastases (MBM) and leptomeningeal metastases (LMM) are two manifestations of melanoma CNS metastasis with vastly different survival outcomes. Using single cell RNA-Seq analysis we uncovered a unique, immune-suppressed T-cell landscape in the LMM microenvironment distinct from that of brain and skin metastases. An LMM patient with an unusually long survival demonstrated...

Subject

Brain Neoplasms

Meningeal Neoplasms

RNA-Seq

Single-Cell Gene Expression Analysis

T-Lymphocytes

Tumor Microenvironment

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