Yeast ORC sumoylation status fine-tunes origin activity

Authors

Regan-Mochrie, Gemma

Zhao, Xiaolan

Description

Sumoylation is emerging as a post-translation modification important for chromosome duplication and stability. The origin recognition complex (ORC), which directs DNA replication initiation by loading the MCM replicative helicases onto origins, is sumoylated in both yeast and human cells. However, the biological consequences of ORC sumoylation are largely unclear. Here we report the effects of hyper-...

Subject

DNA Replication

Minichromosome Maintenance Proteins

Origin Recognition Complex

Sumoylation

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