Copper depletion modulates OXPHOS in SOX2/OCT4+ cancer cells to impair triple negative breast cancer metastasis.

Authors

Li, Zhuoning

Mittal, Vivek

Description

Description from PRIDE: "Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been associated with a significant survival benefit in high-risk triple negative breast cancer (TNBC) patients. Despite these promising data, the mechanisms by which copper depletion impacts metastasis...

Subject

Copper Transport Proteins

Mitochondria/metabolism

Neoplasm Metastasis

Proteomics

Triple Negative Breast Neoplasms

Access Rights

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