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Somatic Loss of Wild-Type Kras Enhances Cancer Fitness and Promotes MEK Dependence
- Authors
- Burgess, Michael R.Hwang, EugeneMroue, RanaBielski, Craig18 more author(s)...
- Description
Summary from the GEO: "Investigating therapeutic “outliers” that show exceptional responses to anti-cancer treatment can reveal unexpected synthetic lethal interactions and uncover biomarkers of drug sensitivity. Preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in KrasG12D “knock-in” mice showed that the MEK inhibitor PD0325901...
- Subject
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Leukemia, Myeloid, AcuteMitogen-Activated Protein Kinase Kinases
- Access Rights
- Free to All
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RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
- Authors
- Berres, Marie-LuiseHogstad, BrandonChakraborty, RikhiaAllen, Carl E1 more author(s)...
- Description
Summary from GEO: " Expression data from dendritic cell subsets derived or sorted from control littermate and CD11c-Cre/BRAFV600E(flox-CA) mice Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately...
- Subject
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bcl-X ProteinDendritic CellsHistiocytosis, Langerhans-CellMitogen-Activated Protein Kinase KinasesProto-Oncogene Proteins B-rafReceptors, CCR7
- Access Rights
- Free to All