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  • Somatic Loss of Wild-Type Kras Enhances Cancer Fitness and Promotes MEK Dependence

    Authors
    Burgess, Michael R.
    Hwang, Eugene
    Mroue, Rana
    Bielski, Craig
    18 more author(s)...
    Description

    Summary from the GEO: "Investigating therapeutic “outliers” that show exceptional responses to anti-cancer treatment can reveal unexpected synthetic lethal interactions and uncover biomarkers of drug sensitivity. Preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in KrasG12D “knock-in” mice showed that the MEK inhibitor PD0325901...

    Subject
    Leukemia, Myeloid, Acute
    Mitogen-Activated Protein Kinase Kinases
    Access Rights
    Free to All
  • RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

    Authors
    Berres, Marie-Luise
    Hogstad, Brandon
    Chakraborty, Rikhia
    Allen, Carl E
    1 more author(s)...
    Description

    Summary from GEO: " Expression data from dendritic cell subsets derived or sorted from control littermate and CD11c-Cre/BRAFV600E(flox-CA) mice Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately...

    Subject
    bcl-X Protein
    Dendritic Cells
    Histiocytosis, Langerhans-Cell
    Mitogen-Activated Protein Kinase Kinases
    Proto-Oncogene Proteins B-raf
    Receptors, CCR7
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    Free to All