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  • CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [ATAC-Seq]

    Authors
    Dunbar, Andrew
    Hoffman, Ronald
    Koche, Richard Patrick
    Levine, Ross L.
    Description

    Summary from GEO: "Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Interleukin-8
    Myeloproliferative Disorders
    Primary Myelofibrosis
    Receptors, Interleukin-8B
    Access Rights
    Free to All

  • CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [RNA-Seq]

    Authors
    Dunbar, Andrew
    Koche, Richard Patrick
    Levine, Ross L.
    Hoffman, Ronald
    Description

    Summary from GEO: "Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be...

    Subject
    Interleukin-8
    Myeloproliferative Disorders
    Primary Myelofibrosis
    Receptors, Interleukin-8B
    RNA-Seq
    Access Rights
    Free to All