Oncogenomics of Malignant Peripheral Nerve Sheath Tumors

Authors

Chi, Ping

Lee, William

Description

Description from dbGaP: "Malignant peripheral nerve sheath tumors (MPNSTs) are a group of highly aggressive soft tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1-associated), or after radiotherapy (RT-associated). We utilized comprehensive genomic approaches and identified recurrent loss-of-function somatic alterations in the Polycomb repressive complex...

Subject

Nerve Sheath Neoplasms

Neurofibromatosis 1

Polycomb Repressive Complex 2

RNA-Seq

Whole Genome Sequencing

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