High response rate to anti PD-1 therapy in desmoplastic melanoma

Authors

Ribas, Antoni

Description

Study Description from dbGaP: Desmoplastic melanoma (DM) is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, but is highly associated with ultraviolet light DNA damage. We analysed 60 patients with advanced DM treated with programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1) blocking antibody therapy. Objective...

Subject

CD8-Positive T-Lymphocytes

Immune Checkpoint Inhibitors

Melanoma

Neurofibromin 1

Programmed Cell Death 1 Receptor

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