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  • A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [multiome scATAC-seq]

    Authors
    Brown, Chrysothemis C.
    Tayyebi, Zakieh
    Description

    Summary from GEO: "Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. A second wave of Treg cell differentiation...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Dendritic Cells
    Epithelial Cells
    Nuclear Receptor Subfamily 1, Group F, Member 3
    Single-Cell Gene Expression Analysis
    T-Lymphocytes, Regulatory
    Access Rights
    Free to All

  • A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [Smart-seq2]

    Authors
    Brown, Chrysothemis C.
    Rudensky, Alexander Y.
    Tayyebi, Zakieh
    Leslie, Christina
    Description

    Summary from GEO: "Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. A second wave of Treg cell differentiation...

    Subject
    Dendritic Cells
    Epithelial Cells
    Nuclear Receptor Subfamily 1, Group F, Member 3
    Single-Cell Analysis
    T-Lymphocytes, Regulatory
    Access Rights
    Free to All

  • A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [multiome scRNA-seq]

    Authors
    Brown, Chrysothemis C.
    Tayyebi, Zakieh
    Description

    Summary from GEO: "Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. A second wave of Treg cell differentiation...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Dendritic Cells
    Epithelial Cells
    Nuclear Receptor Subfamily 1, Group F, Member 3
    Single-Cell Gene Expression Analysis
    T-Lymphocytes, Regulatory
    Access Rights
    Free to All