Chromosomal instability promotes metastasis through a cytosolic DNA response

Authors

Bakhoum, Samuel F

Ngo, Bryan

Description

Summary from the GEO: " Chromosomal instability (CIN) is a hallmark of cancer, and it results from ongoing errors in chromosome segregation during mitosis. While CIN is a major driver of tumor evolution, its role in metastasis has not been established. Here we show that CIN promotes metastasis by sustaining a tumor-cell autonomous inflammatory response to cytosolic DNA. Errors in chromosome segregation...

Subject

Chromosomal Instability

Chromosome Segregation

Cytosol

Membrane Proteins

NF-kappa B

Nucleotidyltransferases

Access Rights

Free to All