Novel metabolic adaptation promotes enhanced macrophage efferocytosis under a limited-oxygen environment

Authors

Wang, Ya-Ting

Trzeciak, Alissa J.

Rojas, Waleska Saitz

Saavedra, Pedro

7 more author(s)...

Description

Summary from GEO: "Apoptotic cell clearance (efferocytosis), a process essential for organismal homeostasis, is performed by phagocytes that inhabit a wide range of environments, including physiologic hypoxia. Here, we find macrophages, the predominant tissue-resident phagocyte, display enhanced efferocytosis under chronic hypoxia, characterized by increased internalization and accelerated degradation...

Subject

Efferocytosis

Hypoxia

Macrophages

MicroRNAs

Pentose Phosphate Pathway

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