PI3K inhibition activates SGK1 via a feedback loop to promote chromatin-based regulation of ER-dependent gene expression

Authors

Toska, Eneda

Koche, Richard Patrick

Description

Summary from GEO: "The phosphoinositide 3-kinase (PI3K) pathway integrates extracellular stimuli to phosphorylate and activate key downstream effectors such as AKT and serum-and glucocorticoid-inducible kinase (SGK1). We have previously reported that the PI3K pathway regulates ER-dependent transcription in breast cancer through the phosphorylation of the epigenetic regulator KMT2D by AKT. Here, we...

Subject

Chromatin Assembly and Disassembly

Phosphatidylinositol 3-Kinase

Phosphoinositide-3 Kinase Inhibitors

Phosphorylation

Receptors, Estrogen

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