This dataset contains the summary data visualizations and clinical data from whole exome sequencing of 114 metastatic tumor/normal pairs from 81 patients. Clinical data includes: Cancer Type, Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, CLONET Purity, Control Site, Disease code, Genomic Burden, Oncotree Code, Other Sample ID, Pathology Classification, Ploidy, Tumor Disease...

Description from PRIDE: "Minor intron-containing genes (MIGs) are crucial cell cycle regulators and are essential for cell survival. Thus, we explored whether MIGs play a role in cancer progression and cancer therapy resistance. Here we show that MIG-expression segregates sensitive and resistant prostate cancer cells from each other and them from benign tissue. Moreover, the rate of minor intron...

Description from EGA: "scRNAseq data of scrambled and siRNA-mediated knock-down (96h) of the minor spliceosome snRNA U6atac in androgen-sensitive LNCaP cells and in patient derived neuroendocrine organoids (PM154). Three replicates for each cell line."

Description from EGA: "Bulk RNAseq data of scrambled and siRNA-mediated knock-down of the minor spliceosome snRNA U6atac in androgen-sensitive LNCaP cells (L), androgen-insensitive C4-2 (C) and 22Rv1 (R) cells and in patient derived neuroendocrine organoids PM154 (P)."

Description from Mendeley Data: "Men with androgen receptor-negative castration-resistant prostate cancer (ARN CRPC) do not benefit from androgen receptor-directed therapies, face low survival rates, and have few alternative therapeutic options. Addressing this unmet clinical need requires new approaches to identify this more aggressive form of disease early on and to treat it effectively. A recent...