Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

Authors

Huang, Hsin-Che

Orth-He, Elizabeth L.

Bachovchin, Daniel

Description

Summary from GEO: "We report the application of RNA-seq for profiling gene transcription upon treatment of methyl bestatin (MeBs, aminopeptidase inhibitor) or brefeldin A (BFA, ER-to-Golgi transport inhibitor), compared to DMSO control. We found MeBs and BFA similarly upregulated genes pertinent to proteotoxic stress." Overall design from GEO: "Examination of gene transcription levels upon treatment...

Subject

Gene Knockout Techniques

Inflammasomes

Protein Folding

Proteotoxic Stress

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Free to All