Histone H3 lysine 4 trimethylation regulates RNA polymerase II promoter-proximal pause-release

Authors

Shliaha, Pavel

Hendrickson, Ronald C.

Description

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and proposed to regulate transcription initiation. However, redundant functions of the H3K4 SET1/COMPASS methyltransferase complexes complicate elucidation of the specific role of H3K4me3 in transcriptional regulation. Here, we show that acute ablation of shared subunits of the SET1/COMPASS complexes leads...

Subject

DNA-Directed RNA Polymerases

Histone Demethylases

Histones

Methylation

RNA Polymerase II

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