Summary from GEO: "Recurrent mutations in the spliceosome are observed in several human cancers but their functional and therapeutic significance remain elusive. SF3B1, the most frequently mutated component of the spliceosome in cancer, is involved in the recognition of the branch point sequence (BPS) during selection of the 3’ splice site (ss) in RNA splicing. Here, we report that common and tumor-specific...

Description from GitHub: "scVelo is a scalable toolkit for RNA velocity analysis in single cells; RNA velocity enables the recovery of directed dynamic information by leveraging splicing kinetics. scVelo collects different methods for inferring RNA velocity using an expectation-maximization framework, deep generative modeling, or metabolically labeled transcripts. scVelo's key applications: -...