Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model

Authors

Price, Jessica C.

Azizi, Elham

Parvani, Jenny G.

Shukla, Priyanka

5 more author(s)...

Description

Summary from GEO: "High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis and rapid metastasis throughout the peritoneal cavity. Previous studies have shown that expression of Notch3 correlates with worse prognosis and increased tumorigenic cell behaviors in HGSC. We investigated the mechanistic role of Notch3 in...

Subject

Carcinogenesis

Carcinoma, Ovarian Epithelial

Epithelial Cells

Ovarian Neoplasms

Receptor, Notch3

RNA-Seq

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