Summary from dbGap: "A subset of advanced prostate cancers can progress from an androgen receptor (AR)-driven state to AR independence, often associated with low or absent AR expression and extensive neuroendocrine differentiation. Once neuroendocrine prostate cancer (NEPC) develops, patients typically demonstrate an aggressive clinical course and poor overall survival. Early diagnosis is important...

Description from Mendeley Data: "Men with androgen receptor-negative castration-resistant prostate cancer (ARN CRPC) do not benefit from androgen receptor-directed therapies, face low survival rates, and have few alternative therapeutic options. Addressing this unmet clinical need requires new approaches to identify this more aggressive form of disease early on and to treat it effectively. A recent...