RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Authors

Berres, Marie-Luise

Hogstad, Brandon

Chakraborty, Rikhia

Allen, Carl E

1 more author(s)...

Description

Summary from GEO: " Expression data from dendritic cell subsets derived or sorted from control littermate and CD11c-Cre/BRAFV600E(flox-CA) mice Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately...

Subject

bcl-X Protein

Dendritic Cells

Histiocytosis, Langerhans-Cell

Mitogen-Activated Protein Kinase Kinases

Proto-Oncogene Proteins B-raf

Receptors, CCR7

Access Rights

Free to All