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  • Characterization of ER, GR, and FoxA1 binding patterns in breast cancer cells treated with either Dex or E2

    Authors
    Swinstead, Erin E.
    Baek, Songjoon
    Hager, Gordon L
    Description

    Summary from the GEO: "The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 is well-established as a pioneer factor for steroid receptor recruitment to chromatin. Here we show that ER and GR have the ability to alter the genomic response of FoxA1 to specific binding sites within the genome. These findings...

    Subject
    Breast Neoplasms
    Hepatocyte Nuclear Factor 3-alpha
    Receptors, Estrogen
    Receptors, Glucocorticoid
    Access Rights
    Free to All

  • Characterization of chromatin accessibility through the DNaseI hypersensitivity assay in breast cancer cells treated with either Dex or E2

    Authors
    Swinstead, Erin E.
    Baek, Songjoon
    Hager, Gordon L
    Description

    Summary from the GEO: "The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 is well-established as a pioneer factor for steroid receptor recruitment to chromatin. Here we show that ER and GR have the ability to alter the genomic response of FoxA1 to specific binding sites within the genome. These findings...

    Subject
    Breast Neoplasms
    Hepatocyte Nuclear Factor 3-alpha
    Receptors, Estrogen
    Receptors, Glucocorticoid
    Access Rights
    Free to All