Summary from BioProject: "Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data used for modeling the crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me2. The main summary display for this entry includes information on the experimental data, validation, macromolecules, small molecules, version history and funding identification. Data...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data used for modeling the crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me3. The main summary display for this entry includes information on the experimental data, validation, macromolecules, small molecules, version history and funding identification. Data...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode). The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit,...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode). The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit,...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying native NSD3 bound to 187-bp nucleosome. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification. Data...