An Azidoribose Probe to Track Ketoamine Adducts in Histone Ribose Glycation

Authors

Maksimovic, Igor

David, Yael

Description

Reactive cellular metabolites can modify macromolecules and form adducts known as non-enzymatic covalent modifications (NECMs). Dissecting the mechanisms, regulation and consequences of NECMs, such as glycation, has been challenging due to the complex and often ambiguous nature of the adducts formed. Directly tracking the formation of modifications on key targets to uncover their underlying physiological...

Subject

Histones

Maillard Reaction

Mass spectrometry

Proteomics

Ribose

Access Rights

Free to All