Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers

Authors

Quintanal Villalonga, Alvaro Diego

Rudin, Charles M.

Zhan, Yingqian

Koche, Richard Patrick

Description

Summary from GEO: "In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin 1. Here we explored the role of exportin 1 in NE transformation. We observed upregulated exportin 1 in lung and prostate pre-transformation...

Subject

Active Transport, Cell Nucleus

Adenocarcinoma

Carcinoma, Neuroendocrine

Heterografts

Prostatic Neoplasms

Small Cell Lung Carcinoma

SOXB1 Transcription Factors

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