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Data from: Cell signaling-based classifier predicts response to induction therapy in elderly patients with acute myeloid leukemia
- Authors
- Cesano, AlessandraWillman, Cheryl L.Kopecky, Kenneth J.Gayko, Urte17 more author(s)...
- Description
From Dryad summary: "Abstract: Single-cell network profiling (SCNP) data generated from multi-parametric flow cytometry analysis of bone marrow (BM) and peripheral blood (PB) samples collected from patients >55 years old with non-M3 AML were used to train and validate a diagnostic classifier (DXSCNP) for predicting response to standard induction chemotherapy (complete response [CR] or CR with incomplete...
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AgedAntineoplastic Combined Chemotherapy ProtocolsLeukemia, Myeloid, AcuteSingle-Cell Analysis
- Access Rights
- Free to All
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Tissue-specific features of the T cell repertoire following allogeneic hematopoietic cell transplantation in human and mouse
- Authors
- DeWolf, SusanElhanati, YuvalNichols, KatherineWaters, Nicholas41 more author(s)...
- Description
Summary from Dryad: "Abstract: T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident T cells at sites of pathology in human organs remains poorly understood. We examined the site-specificity of T cell receptor (TCR) repertoires across tissues (5-18 tissues per patient) in prospectively collected autopsies of patients with and without graft-versus-host...
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Graft vs Host DiseaseHematopoietic Stem Cell TransplantationReceptors, Antigen, T-CellSingle-Cell Analysis
- Access Rights
- Free to All
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Single cell analysis of protein epitopes and chromatin accessibility using PHAGE-ATAC [CD8_Hashing]
- Authors
- Fiskin, EvgenjiLareau, Caleb A.
- Description
Summary from GEO: "Single cell multi-omic readouts of both the cellular transcriptome and proteome have significantly enhanced our ability to comprehensively characterize cellular states. Most approaches in this area rely on oligonucleotide barcode-conjugated antibodies that target cell surface epitopes of interest, enabling their concomitant detection with the transcriptome. However, a similar...
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Chromatin Immunoprecipitation SequencingSingle-Cell AnalysisTranscriptome
- Access Rights
- Free to All
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Single cell analysis of protein epitopes and chromatin accessibility using PHAGE-ATAC [Species_Mix_GFP]
- Authors
- Fiskin, EvgenjiLareau, Caleb A.
- Description
Summary from GEO: "Single cell multi-omic readouts of both the cellular transcriptome and proteome have significantly enhanced our ability to comprehensively characterize cellular states. Most approaches in this area rely on oligonucleotide barcode-conjugated antibodies that target cell surface epitopes of interest, enabling their concomitant detection with the transcriptome. However, a similar high-throughput...
- Subject
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Chromatin Immunoprecipitation SequencingSingle-Cell AnalysisTranscriptome
- Access Rights
- Free to All
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Single cell analysis of protein epitopes and chromatin accessibility using PHAGE-ATAC [Human_PBMCs]
- Authors
- Fiskin, EvgenjiLareau, Caleb A.
- Description
Summary from GEO: "Single cell multi-omic readouts of both the cellular transcriptome and proteome have significantly enhanced our ability to comprehensively characterize cellular states. Most approaches in this area rely on oligonucleotide barcode-conjugated antibodies that target cell surface epitopes of interest, enabling their concomitant detection with the transcriptome. However, a similar...
- Subject
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Chromatin Immunoprecipitation SequencingSingle-Cell AnalysisTranscriptome
- Access Rights
- Free to All
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Single-cell multi-modal profiling of proteins and chromatin accessibility using PHAGE-ATAC [Spike_mix_pbmcs]
- Authors
- Fiskin, EvgenjiLareau, Caleb A.
- Description
Summary from GEO: "Multi-modal measurements of single cell profiles are a powerful tool for characterizing cell states and regulatory mechanisms. While current methods allow profiling of RNA along with either readouts of chromatin or protein, connecting chromatin state to protein levels remains a barrier. Here, we developed PHAGE-ATAC, a method that uses engineered camelid single-domain antibody...
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Chromatin Immunoprecipitation SequencingSingle-Cell AnalysisTranscriptome
- Access Rights
- Free to All
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Single-cell multi-modal profiling of proteins and chromatin accessibility using PHAGE-ATAC [ASAP_Phage_comparison]
- Authors
- Fiskin, EvgenjiLareau, Caleb A.
- Description
Summary from GEO: "Multi-modal measurements of single cell profiles are a powerful tool for characterizing cell states and regulatory mechanisms. While current methods allow profiling of RNA along with either readouts of chromatin or protein, connecting chromatin state to protein levels remains a barrier. Here, we developed PHAGE-ATAC, a method that uses engineered camelid single-domain antibody...
- Subject
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Chromatin Immunoprecipitation SequencingSingle-Cell AnalysisTranscriptome
- Access Rights
- Free to All
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Single-cell multi-modal profiling of proteins and chromatin accessibility using PHAGE-ATAC [Intracellular_GFP]
- Authors
- Fiskin, EvgenjiLareau, Caleb A.
- Description
Summary from GEO: "Multi-modal measurements of single cell profiles are a powerful tool for characterizing cell states and regulatory mechanisms. While current methods allow profiling of RNA along with either readouts of chromatin or protein, connecting chromatin state to protein levels remains a barrier. Here, we developed PHAGE-ATAC, a method that uses engineered camelid single-domain antibody...
- Subject
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Chromatin Immunoprecipitation SequencingSingle-Cell AnalysisTranscriptome
- Access Rights
- Free to All
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [Celline_scATAC]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
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Anemia, SideroblasticBinding sitesFibroblastsGenomicsHeteroplasmy/geneticsMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scRNA]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
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Anemia, SideroblasticGene Expression ProfilingGenomicsHeteroplasmy/geneticsLeukocytes, MononuclearMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All