DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID

Authors

Teater, Matt

Elemento, Olivier

Description

Summary from the GEO: "Changes in DNA methylation are required for the formation of germinal centers (GC), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated recently in DNA demethylation through its deaminase activity coupled with DNA repair. We investigated the epigenetic function of AID in vivo in germinal center B...

Subject

B-Lymphocytes

Cytidine Deaminase

Germinal Center

Somatic Hypermutation, Immunoglobulin

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