Search Tips
of 1 Next >
Results Found: 2
  • Analysis of transcriptomes in intestinal stem cells in response to Interferon gamma

    Authors
    Hanash, Alan
    Takashima, Shuichiro
    Description

    Summary from GEO: "There is limited understanding of how immune-mediated damage impacts intestinal stem cells (ISCs). We found that stem cell compartment injury is a shared feature of both alloreactive and autoreactive intestinal immunopathology, reducing ISCs and impairing their recovery in T-cell-mediated injury models. Modeling with ex vivo epithelial cultures indicated ISC depletion and impaired...

    Subject
    Epithelial Cells
    MicroRNAs
    Stem Cells
    T-Lymphocytes
    Transcriptome
    Access Rights
    Free to All
  • A lymphatic-stem cell interactome regulates intestinal stem cell activity

    Authors
    Niec, Rachel E.
    Chu, Tin Yi
    Gur-Cohen, Shiri
    Schernthanner, Marina
    2 more author(s)...
    Description

    Summary from GEO: "Single-cell RNA-sequencing of murine small intestinal organoid cultured with and without lymphatic endothelial cells: Purpose: To identify differences in cell composition in murine organoids upon coculture with lymphatic endothelial cells Results: We recovered 818 cells with a median of 37750 UMIs per cell for the organoid alone and 1233 cells with a median of 79354 UMIs per cells...

    Subject
    Endothelial Cells
    Intestinal Mucosa
    RNA-Seq
    Single-Cell Analysis
    Stem Cells
    Transcriptome
    Access Rights
    Free to All