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  • Data from: Th2 cytokines inhibit lymphangiogenesis

    Authors
    Savetsky, Ira L.
    Ghanta, Swapna
    Gardenier, Jason C.
    Torrisi, Jeremy S.
    5 more author(s)...
    Description

    Summary from Dryad: "Abstract: Lymphangiogenesis is the process by which new lymphatic vessels grow in response to pathologic stimuli such as wound healing, inflammation, and tumor metastasis. It is well-recognized that growth factors and cytokines regulate lymphangiogenesis by promoting or inhibiting lymphatic endothelial cell (LEC) proliferation, migration and differentiation. Our group has shown...

    Subject
    Endothelial Cells
    Interleukin-13
    interleukin-4
    Lymphangiogenesis
    Th2 Cells
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  • Transforming Growth Factor-b Suppresses Type 2 Immunity to Cancer

    Authors
    Liu, Ming
    Kuo, Fengshen
    Li, Ming O.
    Description

    Summary from GEO: "The immune system employs two distinct defense strategies against infections: pathogen elimination typified by type 1 immunity, and pathogen containment exemplified by type 2 immunity concomitant with tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological...

    Subject
    CD4-Positive T-Lymphocytes
    interleukin-4
    Th2 Cells
    Transforming Growth Factor beta
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