Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis

Authors

Leibold, Josef

Ruscetti, Marcus

Cao. Zhen

Ho, Yu-jui

20 more author(s)...

Description

Summary from GEO: "To study genetic factors that influence the progression and therapeutic response of advanced prostate cancer, we developed a fast and flexible system that introduces genetic alterations relevant to human disease directly into the prostate glands of mice using tissue electroporation. These electroporation based genetically engineered mouse models (EPO-GEMM) recapitulate features...

Subject

Prostatic Neoplasms

RNA-Seq

Tissue Engineering

Wnt Signaling Pathway

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