The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

Authors

Polaski, Jacob T.

Kannan, Ram

Bradley, Robert K.

Description

Summary from the GEO: "Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a core nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The corresponding controversy about whether UPF1 mutations are important contributors...

Subject

Carcinoma, Adenosquamous

Pancreatic Neoplasms

RNA Helicases

Trans-Activators

Access Rights

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