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Results Found: 3
  • Flura-Seq Identifies In Situ Transcriptomes of Micrometastases

    Authors
    Basnet, Harihar
    Macalinao, Danilo Reynaldo Galindez
    Massagué, Joan
    Description

    Summary from the GEO: "Understanding the biology of rare cell populations in the context of their microenvironment requires an accurate analysis of the transcriptomes of these cells as expressed in situ. We developed fluorouracil-tagged RNA sequencing (Flura-seq) to characterize the transcriptomes of small cell subpopulations from a whole organ in model systems. The method utilizes cytosine deaminase...

    Subject
    Brain Neoplasms
    Breast Neoplasms
    Gene Expression Profiling
    Lung Neoplasms
    Transcriptome
    Transforming Growth Factor beta
    Access Rights
    Free to All
  • Transforming Growth Factor-b Suppresses Type 2 Immunity to Cancer

    Authors
    Liu, Ming
    Kuo, Fengshen
    Li, Ming O.
    Description

    Summary from GEO: "The immune system employs two distinct defense strategies against infections: pathogen elimination typified by type 1 immunity, and pathogen containment exemplified by type 2 immunity concomitant with tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological...

    Subject
    CD4-Positive T-Lymphocytes
    interleukin-4
    Th2 Cells
    Transforming Growth Factor beta
    Access Rights
    Free to All
  • ID1 mediates escape from TGFβ Tumor Suppression in Pancreatic Cancer

    Authors
    Huang, Yun-Han
    Massagué, Joan
    Description

    Summary from GEO: "We perform ChIPseq, ATACseq, and RNAseq to characterize the role of ID1 in PDA cells." Overall design from GEO: "ChIPseq, RNAseq, and ATACseq are used to profile PDA cells"

    Subject
    Carcinoma, Pancreatic Ductal
    Chromatin Immunoprecipitation Sequencing
    Inhibitor of Differentiation Protein 1
    Pancreatic Neoplasms
    RNA-Seq
    Transforming Growth Factor beta
    Access Rights
    Free to All