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  • Innate, Transcriptomic, and Microbiomic Correlates of Tuberculosis Infection and Disease

    Description

    Description from BioProject: "The lifecycle of M. tuberculosis within the human host is marked by critical transition points between the major phases of infection: Initial infection, latent disease, active tuberculosis, and resolution with antibiotic therapy. Through observation of patients in each of these stages, we have some knowledge about host determinants that maintain each of these stages,...

    Subject
    Gastrointestinal Microbiome
    Mucosal-Associated Invariant T Cells
    Tuberculosis
    Access Rights
    Free to All
  • Single cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation

    Authors
    Krishna, Chirag
    Leslie, Christina
    Description

    Summary from GEO: "Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize microbial vitamin B metabolites and have emerging roles in infectious disease, autoimmunity, and cancer. Although MAIT cells are identified by a semi-invariant T cell receptor, their phenotypic and functional heterogeneity is not well understood. Here we present an integrated single cell transcriptomic...

    Subject
    Mucosal-Associated Invariant T Cells
    Receptors, Antigen, T-Cell
    Single-Cell Analysis
    Transcriptome
    Tuberculosis
    Access Rights
    Free to All