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Innate, Transcriptomic, and Microbiomic Correlates of Tuberculosis Infection and Disease
- Description
Description from BioProject: "The lifecycle of M. tuberculosis within the human host is marked by critical transition points between the major phases of infection: Initial infection, latent disease, active tuberculosis, and resolution with antibiotic therapy. Through observation of patients in each of these stages, we have some knowledge about host determinants that maintain each of these stages,...
- Subject
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Gastrointestinal MicrobiomeMucosal-Associated Invariant T CellsTuberculosis
- Access Rights
- Free to All
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Single cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
- Authors
- Krishna, ChiragLeslie, Christina
- Description
Summary from GEO: "Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize microbial vitamin B metabolites and have emerging roles in infectious disease, autoimmunity, and cancer. Although MAIT cells are identified by a semi-invariant T cell receptor, their phenotypic and functional heterogeneity is not well understood. Here we present an integrated single cell transcriptomic...
- Subject
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Mucosal-Associated Invariant T CellsReceptors, Antigen, T-CellSingle-Cell AnalysisTranscriptomeTuberculosis
- Access Rights
- Free to All