Mll3 suppresses tumorigenesis by activating the Ink4a/Arf locus

Authors

Soto-Feliciano, Yadira M.

Zhu, Changyu

Morris IV, John P.

Huang, Chun-Hao

13 more author(s)...

Description

Summary from Dryad: "Abstract: Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemia family member 3 (MLL3/KMT2C) histone methyltransferase occur in a range of solid tumors and heterozygous deletions encompassing...

Subject

Carcinogenesis/genetics

Carcinoma, Hepatocellular

Cyclin-Dependent Kinase Inhibitor p16

Leukemia

Tumor Suppressor Protein p14ARF

Access Rights

Free to All