Spectrum of Viral Load and Host Response Seen in Autopsies of SARS-CoV-2 Infected Lungs

Authors

Desai, Neil B.

Neyaz, Azfar

Szabolcs, Annamaria

Shih, Angela R.

18 more author(s)...

Description

Summary from the GEO: "The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We visualized viral RNA by in situ hybridization and assessed the immune infiltrate using immunohistochemistry and total RNA sequencing on five COVID-19 positive patients. Patients with high levels of viral RNA showed hyaline membranes on histology, extensive pneumocyte loss,...

Subject

Alveolar Epithelial Cells

COVID-19

Hyalin

SARS-CoV-2

T-Lymphocytes

Viral Load