The IRE1-XBP1 pathway promotes natural killer cell responses against viral infection and cancer by regulation of c-Myc

Authors

Dong, Han

Adams, Nicholas M.

Xu, Yichi

Cao, Jin

5 more author(s)...

Description

Summary from GEO: "Natural killer (NK) cells are critical mediators of host immunity against infectious disease and cancer. The intrinsic regulators of NK cells are not fully understood. Here, we demonstrate that the ER stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) critically drive NK cell-mediated responses against viral infection...

Subject

Genes, myc

Killer Cells, Natural

Receptors, Estrogen

Transcription Factors

Transcriptome

X-Box Binding Protein 1

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