Genetic analysis of HLA and immune escape genes in Diffuse Large B-cell Lymphoma

Description

Study Description from EGA: "Fifty percent of diffuse large B-cell lymphoma (DLBCL) cases lack cell-surface expression of the class-I major histocompatibility complex (MHC-I), thereby escaping immune recognition by cytotoxic T cells. In order to comprehensively identify the mechanisms involved in MHC-I loss, we first performed immunophenotypic analysis of both MHC class-I and -II in 657 cases across...

Subject

beta 2-Microglobulin

Histocompatibility Antigens Class I

HLA Antigens

Lymphoma, Large B-Cell, Diffuse

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