Summary from the GEO: "Recent clinical data has suggestedsed a bi-directional relationship between Coronavirus disease 19 (COVID-19) and diabetes. Here, we showdemonstrateed the detection of SARS-CoV-2 in pancreatic endocrine cells in autopsy samples derived fromof COVID-19 patients. Single cell RNA-seq and immunostaining confirmed that multiple types of pancreatic islet cells can be infected byare...

Summary from GitHub: This repository contains the R scripts necessary to perform the analysis in our paper Tang, Xuming et al. “SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation.” Cell Metabolism, 19 May. 2021, doi:10.1016/j.cmet.2021.05.015, as described in the supplementary methods and main text." Input data: "The single cell RNA-seq data were generated with the 10X Chromium and pre-processed...

Summary from the GEO: "The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public health threat due to the lack of effective drugs or vaccines against SARS-CoV-2. The efficacy of several repurposed drugs has been evaluated in clinical trials. Among these drugs, a second second-generation antiandrogen...

Summary from the GEO: "The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public health threat due to the lack of effective drugs or vaccines against SARS-CoV-2. The efficacy of several repurposed drugs has been evaluated in clinical trials. Among these drugs, a second second-generation antiandrogen...

Method for Data Collection to GWAS Catalog submission: "The GWAS conducted by an international consortium group involved 1980 patients with severe acute respiratory failure induced by COVID-19 at seven hospitals in Italy and Spain [7]. After quality control, the final case-control cohort included 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from...

Summary from the GEO: "The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed specimens from 24 autopsies from patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of...

Summary from the GEO: " The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed specimens from 24 autopsies from patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of...

Summary from the GEO: "The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We visualized viral RNA by in situ hybridization and assessed the immune infiltrate using immunohistochemistry and total RNA sequencing on five COVID-19 positive patients. Patients with high levels of viral RNA showed hyaline membranes on histology, extensive pneumocyte loss,...

Method for Data Collection to GWAS Catalog submission: "The GWAS conducted by an international consortium group involved 1980 patients with severe acute respiratory failure induced by COVID-19 at seven hospitals in Italy and Spain [7]. After quality control, the final case-control cohort included 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from...