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A multivalent signal-transducing model for the DNMT1-mediated maintenance DNA methylation
- Authors
- Wang, Gang G.Grimm, Sara A.
- Description
Summary from the GEO: "Heterochromatin-specific histone modifications frequently coexist with mammalian DNA methylation to orchestrate a repressive chromatin state. However, it remains elusive how these epigenetic modifications crosstalk. Here, we report that the first bromoadjacent homology (BAH1) domain and the replication foci targeting sequence (RFTS) of maintenance DNA methyltransferase DNMT1...
- Subject
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DNA (Cytosine-5-)-Methyltransferase 1DNA MethylationHeterochromatinHistone CodeHistones
- Access Rights
- Free to All
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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting tumor mutation burden
- Authors
- Schvartzman, Juan-ManuelKoche, Richard PatrickThompson, Craig B.
- Description
Summary from GEO: "Oncogenic mutations in the metabolic enzyme isocitrate dehydrogenase 1 and 2 (IDH1/2) have been found in a number of liquid and solid tumors. Their pathogenic mechanism of action involves production of 2-hydroxyglutarate (2HG), an oncometabolite that acts in part by inhibiting members of a family of dioxygenases that modulate chromatin dynamics. Recent work has suggested that mutant...
- Subject
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DNA ReplicationHeterochromatinIsocitrate DehydrogenasePoly ADP RibosylationPoly(ADP-ribose) Polymerase Inhibitors
- Access Rights
- Free to All