Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)

Authors

Kharas, Michael G.

Lengner, Christopher J.

Al-Shahrour, Fatima

Bullinger, Lars

16 more author(s)...

Description

Summary from the GEO: "We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressive leukemia. MSI2 is over-expressed in human myeloid leukemia, and expression...

Subject

Leukemia, Myeloid, Acute

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