Description from MassIVE: Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...

Summary from GEO: "In an effort to identify novel differentially-expressed genes in OA, we performed RNA-seq analysis using cartilage isolated from nonarthritic and OA patients. Total RNA was isolated from 3 samples of nonarthritic cartilage and 4 samples of OA cartilage (Kellgren-Lawrence Grade 3 or 4). Genes (900 total, 600 up-regulated, 300 down-regulated) were differentially expressed in OA vs....

Dataset Description from EGA: " Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor of multiple myeloma (MM) with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations, RB1 deletion, 1q gain, hyperdiploidy or RAS genes mutations, little is known about molecular mechanism of...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the AacC2c1-sgRNA-extended target DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA-8mer substrate DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA-extended non-target DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA binary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction  data identifying the crystal structure of Sec23a/Sec24a/Sec22 complexed with Emp24 sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal VV sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction  data identifying the crystal structure of Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal II sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included...