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  • (Metabolome analysis data): Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

    Authors
    Kitamura, Toshio
    Description

    Description from MassIVE: Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...

    Subject
    Clonal Hematopoiesis
    Hematopoietic Stem Cells
    Metabolome
    Myelodysplastic Syndromes
    Access Rights
    Free to All
  • 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis

    Authors
    Fu, Wenyu
    Hettinghouse, Aubryanna
    Hu, Wenhuo
    Liu, Chuan-Ju
    Description

    Summary from GEO: "In an effort to identify novel differentially-expressed genes in OA, we performed RNA-seq analysis using cartilage isolated from nonarthritic and OA patients. Total RNA was isolated from 3 samples of nonarthritic cartilage and 4 samples of OA cartilage (Kellgren-Lawrence Grade 3 or 4). Genes (900 total, 600 up-regulated, 300 down-regulated) were differentially expressed in OA vs....

    Subject
    14-3-3 Proteins
    Gene Expression Profiling
    MicroRNAs
    Osteoarthritis
    Receptors, Tumor Necrosis Factor, Type II
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    Free to All
  • 33 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS)

    Description

    Dataset Description from EGA: " Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor of multiple myeloma (MM) with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations, RB1 deletion, 1q gain, hyperdiploidy or RAS genes mutations, little is known about molecular mechanism of...

    Subject
    Monoclonal Gammopathy of Undetermined Significance
    Multiple Myeloma
    Oncogene Proteins, Fusion
    Access Rights
    Application Required
  • 5U30: Crystal structure of AacC2c1-sgRNA-extended target DNA ternary complex

    Authors
    Yang, Hui
    Gao, Pu
    Rajashankar, Kanagalaghatta R.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the AacC2c1-sgRNA-extended target DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....

    Subject
    CRISPR-Cas Systems
    Models, Chemical
    Models, Molecular
    Access Rights
    Free to All
  • 5U31: Crystal structure of AacC2c1-sgRNA-8mer substrate DNA ternary complex

    Authors
    Yang, Hui
    Gao, Pu
    Rajashankar, Kanagalaghatta R.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA-8mer substrate DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history...

    Subject
    CRISPR-Cas Systems
    Models, Chemical
    Models, Molecular
    Access Rights
    Free to All
  • 5U33: Crystal structure of AacC2c1-sgRNA-extended non-target DNA ternary complex

    Authors
    Yang, Hui
    Gao, Pu
    Rajashankar, Kanagalaghatta R.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA-extended non-target DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version...

    Subject
    CRISPR-Cas Systems
    Models, Chemical
    Models, Molecular
    Access Rights
    Free to All
  • 5U34: Crystal structure of AacC2c1-sgRNA binary complex

    Authors
    Yang, Hui
    Gao, Pu
    Rajashankar, Kanagalaghatta R.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA binary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....

    Subject
    CRISPR-Cas Systems
    Models, Chemical
    Models, Molecular
    Access Rights
    Free to All
  • 5VNE: Crystal structure of Sec23a/Sec24a/Sec22 complexed with Emp24 sorting motif

    Authors
    Ma, Wenfu
    Goldberg, Jonathan
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction  data identifying the crystal structure of Sec23a/Sec24a/Sec22 complexed with Emp24 sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version...

    Subject
    Models, Chemical
    Models, Molecular
    Protein Binding
    Protein Transport
    Access Rights
    Free to All
  • 5VNF: Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal VV sorting motif

    Authors
    Ma, Wenfu
    Goldberg, Jonathan
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal VV sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and...

    Subject
    Binding sites
    Models, Chemical
    Models, Molecular
    Protein Transport
    Access Rights
    Free to All
  • 5VNG: Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal II sorting motif

    Authors
    Ma, Wenfu
    Goldberg, Jonathan
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction  data identifying the crystal structure of Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal II sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included...

    Subject
    Models, Chemical
    Models, Molecular
    Protein Binding
    Protein Transport