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(Metabolome analysis data): Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
- Authors
- Kitamura, Toshio
- Description
Description from MassIVE: Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...
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Clonal HematopoiesisHematopoietic Stem CellsMetabolomeMyelodysplastic Syndromes
- Access Rights
- Free to All
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14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis
- Authors
- Fu, WenyuHettinghouse, AubryannaHu, WenhuoLiu, Chuan-Ju
- Description
Summary from GEO: "In an effort to identify novel differentially-expressed genes in OA, we performed RNA-seq analysis using cartilage isolated from nonarthritic and OA patients. Total RNA was isolated from 3 samples of nonarthritic cartilage and 4 samples of OA cartilage (Kellgren-Lawrence Grade 3 or 4). Genes (900 total, 600 up-regulated, 300 down-regulated) were differentially expressed in OA vs....
- Subject
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14-3-3 ProteinsGene Expression ProfilingMicroRNAsOsteoarthritisReceptors, Tumor Necrosis Factor, Type II
- Access Rights
- Free to All
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184-hTERT-L2 direct library preparation (DLP) single-cell genomes
- Description
Description from EGA: "Microfluidic direct library preparation (DLP) single-cell whole-genome BAM files for near-diploid immortalized breast epithelial cell line 184-hTERT-L2."
- Subject
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Epithelial CellsMicrofluidic Analytical TechniquesSingle-Cell AnalysisWhole Genome Sequencing
- Access Rights
- Free to All
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184-hTERT-L2, SA501X3F, and SA501X4F bulk genomes
- Description
Description from EGA: "Bulk whole-genome BAM files for 184-hTERT-L2, SA501X3F, and SA501X4F."
- Subject
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Epithelial CellsTriple Negative Breast NeoplasmsWhole Genome Sequencing
- Access Rights
- Free to All
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33 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Description
Dataset Description from EGA: " Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor of multiple myeloma (MM) with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations, RB1 deletion, 1q gain, hyperdiploidy or RAS genes mutations, little is known about molecular mechanism of...
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Monoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaOncogene Proteins, Fusion
- Access Rights
- Application Required
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5U30: Crystal structure of AacC2c1-sgRNA-extended target DNA ternary complex
- Authors
- Yang, HuiGao, PuRajashankar, Kanagalaghatta R.Patel, Dinshaw J.
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the AacC2c1-sgRNA-extended target DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....
- Subject
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CRISPR-Cas SystemsModels, ChemicalModels, Molecular
- Access Rights
- Free to All
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5U31: Crystal structure of AacC2c1-sgRNA-8mer substrate DNA ternary complex
- Authors
- Yang, HuiGao, PuRajashankar, Kanagalaghatta R.Patel, Dinshaw J.
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA-8mer substrate DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history...
- Subject
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CRISPR-Cas SystemsModels, ChemicalModels, Molecular
- Access Rights
- Free to All
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5U33: Crystal structure of AacC2c1-sgRNA-extended non-target DNA ternary complex
- Authors
- Yang, HuiGao, PuRajashankar, Kanagalaghatta R.Patel, Dinshaw J.
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA-extended non-target DNA ternary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version...
- Subject
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CRISPR-Cas SystemsModels, ChemicalModels, Molecular
- Access Rights
- Free to All
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5U34: Crystal structure of AacC2c1-sgRNA binary complex
- Authors
- Yang, HuiGao, PuRajashankar, Kanagalaghatta R.Patel, Dinshaw J.
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of the AacC2c1-sgRNA binary complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....
- Subject
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CRISPR-Cas SystemsModels, ChemicalModels, Molecular
- Access Rights
- Free to All
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5VNE: Crystal structure of Sec23a/Sec24a/Sec22 complexed with Emp24 sorting motif
- Authors
- Ma, WenfuGoldberg, Jonathan
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data identifying the crystal structure of Sec23a/Sec24a/Sec22 complexed with Emp24 sorting motif. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version...
- Subject
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Models, ChemicalModels, MolecularProtein BindingProtein Transport
- Access Rights
- Free to All