H3K36 methyltransferase SETD2 regulates lymphoid and neural development [MIXCR]

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UID: 10512

Author(s): Chu, Scott Haihua*, Hatton, Charlie * MSK affiliated

Description: Summary from the GEO: "Complete Amplicon Sequencing of a 500bp V(D)J recombination products from proB cells sorted from control and Setd2KO mice to Vh558, Vh7183 and Vhq52 variable gene familes to JH4 joining gene fragment to determine CDR3. Genomic DNA from proB cells (B220+Cd43+IgM-CD25-) sorted from control and Setd2 knockout mice were isolated and subjected to V(D)J recombination PCR using a primer for either Vh558, Vh7183, or Vhq52 gene families and JH4 gene. This 500bp PCR fragment was extracted and subjected to NGS (single 150bp read of amplicon pair)."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Lymphoid

Access via GEO
Raw and CSV sequencing data.
Accession #: GSE131608

Access via SRA
Sequence reads for 32 samples.
Accession #: SRP199170

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA544179
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Chu S, Chabon J, Matovina C, et al. Loss of H3K36 methyltransferase Setd2 impairs V(D)J recombination during lymphoid development. iScience. 2020; 23(3):100941.
Data Type: Genomic
Equipment Used: Illumina MiSeq (Mus musculus)
Dataset Format(s): CSV, Plain Text, SRA, TAR
Dataset Size: 270.0 Kb (TAR of TXT), 94.0 Kb (CSV), SRA broken up into files totaling 283.89 Mb.

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