Chromatin Landscape Analysis of primary mouse prostate organoid culture with overexpression of FOXA1

Default Boolean Operator: Terms in a search string will be connected by the AND operator, EXAMPLE: searching genomic melanoma will produce the same results as genomic AND melanoma .
AND, OR, NOT: Combine terms in a search with the boolean operators AND (to add specificity), OR (to broaden), or NOT (to eliminate a term). Operators must be capitalized (all other search terms are not case-sensitive).
Wild Card: Add wild card symbols * (open-ended) and ? (single character) to truncate terms. EXAMPLE: searching gen* shows results for 'gene', 'genetic', 'genomic, etc. Searching gene? returns results for 'gene' or 'genes' but not for 'genome'.
Phrase Searching: Enclose search in quotation marks "keyword or search term" to search for an exact phrase. EXAMPLE: "transcription factors" returns results for records where transcription is immediately followed by the word factors .
Diacritics: Words containing diacritics translate those characters to non-diacritic form. EXAMPLE: massague returns results for Massague&#769 .
Filter by: Located on the homepage (left panel), use filters to search for records or narrow the search. From search results page, filters can be removed by clicking on the term at the top of the page.

UID: 10529

Author(s): Adams, Elizabeth*, Sawyers, Charles L.*, Leslie, Christina* * MSK affiliated

Description: Summary from the GEO: "Chromatin Landscape Analysis of primary mouse prostate organoid culture with overexpression of FOXA1.
Examination by genotypes and days elapsed prepared in 3 replicates."

This dataset depicts mutations in the FOXA1 gene, which define a unique subset of prostate cancers.

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Prostate

Access via GEO
Bigwig SRA sequencing data.
Accession #: GSE128421

Access via SRA
ATAC sequence reads for 45 samples.
Accession #: SRP188671

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA527714
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Adams E, Karthaus W, Hoover E, et al. FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature. 2019; 571(7765):408-412.
Data Type: Genomic
Equipment Used: Illumina HiSeq 2500
High throughput sequencing system
Dataset Format(s): SRA, TAR, BIGWIG
Dataset Size: 10.8 Gb (TAR of Bigwig), SRA distributed across 45 files of 1-3 Gb each.

Do you have or know of a dataset that should be added to the catalog? Let us know!